Subacute sclerosing panencephalitis: measles encephalitis of temperate evolution

Subacute sclerosing panencephalitis: measles encephalitis of temperate evolution?

Subacute sclerosing panencephalitis is a rare disorder of late childhood and early adolescence Affected patients usually show behavioural and intellectual disturbance and involuntary movements before dying in coma after about 12 months. At some stage most have characteristic electroencephalographic abnormalities. Pathologically, changes in the brain are those of subacute encephalitis with a var...

Measles immunoglobulins in subacute sclerosing panencephalitis.

Normal responses of measles specific immunoglobulins M and G (IgM and IgG) were defined in 10 children with measles. Abnormal responses of measles IgM and IgG were found in both sera and cerebrospinal fluids from three cases of subacute sclerosing panencephalitis. In two patients the serum titres of measles IgM and IgG were abnormally high. The measles IgM was present during prolonged illnesses...

Subacute Sclerosing Panencephalitis in Iran

[Subacute sclerosing panencephalitis].

Subacute sclerosing panencephalitis is a slowly progressive neurodegenerative disorder occurring in childhood and adolescence and is characterised by dementia, ataxia, myoclonias and other neurological focal signs, with an invariably fatal outcome. The author reviews the subject, focussing on epidemiology, clinical features, measles virus behaviour, host immune reactions, measles prophylaxis an...

Subacute sclerosing panencephalitis.

Introduction Subacute sclerosing panencephalitis (SSPE) is a rare disease which predominantly affects children of school age. The clinical features include an insidious afebrile onset with behavioural disturbance and progressive dementia sometimes associated with epilepsy. Later akinetic mutism and myoclonic jerks with pyramidal and extrapyramidal signs appear. Finally there is progressive deco...